The Center for SMART Health is harnessing a wide range of wearable technologies to provide sophisticated, continuous physical activity tracking methods and objective assessment, while still being unobtrusive and easy to use in daily activities. Our Sensing in At-Risk Populations (SARP) is enabling healthcare providers to gain a detailed understanding of an individual’s functional, mental, and psychological well-being, particularly among frail patients with serious illnesses or high-risk comorbidities. Combining wearable and environmental sensors, wireless devices, and a HIPAA-compliant, cloud-based analytic engine, SARP provides real-time display of a user’s status over time, providing healthcare providers and caregivers a daily storyline. SARP’s algorithms provide for early prediction of rehabilitation failure or success, enabling staff to efficiently triage, admit, and discharge patients.